Hepatic steatosis and hepatic iron overload modify the association of iron markers with glucose metabolism disorders and metabolic syndrome

Background Iron status has been linked with impaired glucose metabolism (IGM), type 2 diabetes mellitus (T2DM) and the metabolic syndrome (MetS), but role of hepatic steatosis or iron overload on these associations remains uncertain. Methods We analysed data from 2310 participants without known T2DM population-based Study Health in Pomerania (SHIP-TREND, Germany) through logistic regression models. tested additive multiplicative interactions between ferritin overload. Results Serum was positively associated IGM (OR per 100 µg/L: 1.11 [1.01, 1.23]), 1.20 [1.06, 1.36]) MetS [1.02, 1.20]) total population as well However, synergistic effect higher concentrations showed stronger T2DM. Similarly, while even absence steatosis, IGM, MetS. Transferrin isolated tolerance not Conclusions Our study suggests that may be disorders people individuals concentrations, presence indicate risk for MetS, only disorders.